NICLOSAMIDE
1) Common name:Niclosamide
2) Chemical name: 2′,5-dichloro-4′-nitrosalicylanilide
3) CAS Number:50-65-7
4) Empirical formula: C13H8Cl2N2O4
5) Molecular weight: 327.12
6) Structural formula:
7) Physical & Chemical Properties:
a. Appearance: Yellowish grey odourless crystalline solid
b. Melting point: 230°C
c. Vapor pressure:<1 mPa at 20°C
d. Solubility:Niclosamide is not very water soluble, 5-8 mg/L at 20 °C, sparingly soluble in ether, ethanol and chloroform, and soluble in acetone; the ethanolamine salt dissolves in distilled water 180-280 mg/L at 20 °C.
8) Stability: In tablets niclosamide undergoes a biodegradation inmoist environments but niclosamide itself is stable in an aqueous solution for several months. The ethanolamine salt is stable to heat, hydrolysed by concentrated acid or alkali, and stable in aquaticenvironments
9) Application: Niclosamide is a relatively selective, non-cumulative chlorinated aromatic amide pesticide; principally used against aquatic snails but also as an antiparasitic drug in human and veterinary medicine. It is of very low toxicity to mammals, can be toxic to aquatic vertebrates(e.g. fish and amphibians) and crustaceans. Niclosamide is non-persistent in the aquatic environment, has a slight effect on aquatic plants and zooplankton but is not generally phytotoxic at field concentrations; For agricultural use, Niclosamide is used effectively against molluscs (especially fresh water snails), and cestode and trematode infestations of humans, livestock, and pets; For public health use, Niclosamide is used effectively against fresh water snails that are intermediate hosts for schistosomiasis and fascioliasis. It has also been used in the control of cestodes infecting man.
10) Product available: Niclosamide 99%min technical, 83% WP
11) Packing: 25kg fiber drum.
